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David J Fink Selected Research

proenkephalin

1/2009Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain.
6/2006Vector-mediated gene transfer to express inhibitory neurotransmitters in dorsal root ganglion reduces pain in a rodent model of lumbar radiculopathy.
11/2003Development of HSV-mediated gene transfer for the treatment of chronic pain.
10/2003Gene therapy for chronic pain.
3/2003Transgene-mediated enkephalin release enhances the effect of morphine and evades tolerance to produce a sustained antiallodynic effect in neuropathic pain.
12/2002Targeted gene delivery to the nervous system using herpes simplex virus vectors.
11/2002Herpes vector-mediated expression of proenkephalin reduces bone cancer pain.

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David J Fink Research Topics

Disease

22Pain (Aches)
09/2013 - 11/2002
15Neuralgia (Stump Neuralgia)
09/2013 - 03/2003
8Chronic Pain
10/2012 - 10/2003
8Hyperalgesia
03/2012 - 06/2005
8Diabetic Neuropathies (Diabetic Neuropathy)
03/2012 - 07/2002
5Spinal Cord Injuries (Spinal Cord Injury)
09/2012 - 07/2004
4Parkinson Disease (Parkinson's Disease)
09/2011 - 11/2003
4Neoplasms (Cancer)
08/2011 - 11/2002
3Polyneuropathies (Polyneuropathy)
10/2012 - 01/2004
3Intractable Pain
03/2012 - 10/2009
3Hyperglycemia
10/2011 - 06/2008
3Herpes Simplex
05/2006 - 07/2002
3Peripheral Nervous System Diseases (PNS Diseases)
02/2003 - 01/2002
1Adenoma (Adenomas)
12/2021
1Spinal Muscular Atrophy (Progressive Muscular Atrophy)
11/2013
1Disease Progression
05/2013
1Myocardial Ischemia (Ischemic Heart Diseases)
01/2012
1Myocardial Infarction
01/2012
1Infections
11/2011
1Wounds and Injuries (Trauma)
04/2010
1Experimental Diabetes Mellitus
04/2009
1Inflammation (Inflammations)
04/2009
1Diarrhea
01/2009
1Radiculopathy (Radiculopathy, Cervical)
06/2006
1Glioma (Gliomas)
08/2005
1Huntington Disease (Huntington's Disease)
01/2004

Drug/Important Bio-Agent (IBA)

9Peptides (Polypeptides)IBA
01/2012 - 01/2002
7Neurotransmitter Agents (Neurotransmitter)IBA
10/2012 - 04/2003
7EnkephalinsIBA
03/2012 - 11/2002
7proenkephalinIBA
01/2009 - 11/2002
6Analgesics (Analgesic Drugs)IBA
08/2011 - 03/2003
5Nerve Growth Factors (Neurotrophins)IBA
10/2012 - 01/2002
5gamma-Aminobutyric Acid (GABA)IBA
03/2012 - 07/2004
5Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA
10/2011 - 07/2004
4Proteins (Proteins, Gene)FDA Link
12/2021 - 01/2004
4Glial Cell Line-Derived Neurotrophic Factor (GDNF)IBA
04/2010 - 09/2003
3Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2013 - 05/2006
3Pharmaceutical PreparationsIBA
05/2013 - 12/2003
3Butyric Acid (Butanoic Acid)IBA
03/2012 - 07/2004
3Morphine (MS Contin)FDA LinkGeneric
08/2011 - 03/2003
3ErythropoietinFDA Link
02/2011 - 11/2006
2Interleukin-10 (Interleukin 10)IBA
09/2012 - 11/2009
2Voltage-Gated Sodium ChannelsIBA
03/2012 - 06/2008
2Small Interfering RNA (siRNA)IBA
11/2011 - 05/2011
2delta Opioid Receptors (delta Opioid Receptor)IBA
10/2011 - 06/2008
2preproenkephalinIBA
08/2011 - 10/2009
2Streptozocin (Streptozotocin)FDA Link
02/2011 - 07/2002
2Neuroprotective AgentsIBA
11/2009 - 11/2006
2endomorphin 2IBA
04/2009 - 12/2007
2Opioid Peptides (Opioid Peptide)IBA
01/2009 - 12/2002
21- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)IBA
11/2006 - 07/2004
2Oxidopamine (6 Hydroxydopamine)IBA
07/2004 - 11/2003
2Therapeutic UsesIBA
01/2004 - 01/2002
1myotubularinIBA
12/2021
1Small Heat-Shock ProteinsIBA
11/2013
1CationsIBA
09/2013
1MicroRNAs (MicroRNA)IBA
03/2012
1Reverse Transcriptase InhibitorsIBA
11/2011
1Zalcitabine (Hivid)FDA Link
11/2011
1NucleosidesIBA
11/2011
1G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA
10/2011
1SynucleinsIBA
09/2011
1rho GTP-Binding Proteins (rho GTP-Binding Protein)IBA
09/2011
1Opiate AlkaloidsIBA
08/2011
1Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA
05/2011
1Messenger RNA (mRNA)IBA
05/2011
1Opioid Analgesics (Opioids)IBA
02/2011
1Substance PIBA
11/2010
1Interleukin-10 ReceptorsIBA
11/2009
1Formaldehyde (Formol)FDA Link
04/2009
1Freund's AdjuvantIBA
04/2009
1Glycogen Synthase Kinase 3 betaIBA
04/2009
1Pilocarpine (Ocusert)FDA LinkGeneric
04/2009
1NeuropeptidesIBA
04/2009
1Calcitonin Gene-Related PeptideIBA
04/2009
1Naloxone (Narcan)FDA LinkGeneric
01/2009
14- (4- fluorophenyl)- 2- (4- hydroxyphenyl)- 5- (4- pyridyl)imidazoleIBA
06/2008
1naltrindoleIBA
06/2008
1Protein Kinase CIBA
06/2008
1imidazoleIBA
06/2008
1PlasticsIBA
02/2008
1mu Opioid Receptors (mu Opioid Receptor)IBA
12/2007
1p38 Mitogen-Activated Protein KinasesIBA
05/2006
1Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2006
1Phosphotransferases (Kinase)IBA
02/2006
1InterleukinsIBA
02/2006
1Dinoprostone (PGE2)FDA Link
02/2006
1Interleukin-4 (Interleukin 4)IBA
02/2006
1Wheat Germ AgglutininsIBA
10/2004
1Wheat Germ Agglutinin-Horseradish Peroxidase ConjugateIBA
10/2004
1Horseradish PeroxidaseIBA
10/2004
1Protein Isoforms (Isoforms)IBA
07/2004
1BicucullineIBA
07/2004
1phaclofenIBA
07/2004
1Antisense RNA (Anti-Sense RNA)IBA
01/2004

Therapy/Procedure

7Therapeutics
03/2012 - 09/2003
6Ligation
09/2013 - 10/2004
1Cell- and Tissue-Based Therapy (Cell Therapy)
01/2012
1Spinal Injections
04/2010
1Drug Therapy (Chemotherapy)
01/2009